NEONATAL VENTILATOR — NIV + DUOPAP + HIGH-FLOW
fabian® Therapy Evolution
The fabian Therapy Evolution (ZOLL) is the neonatal ventilator dedicated to non-invasive respiratory therapy — NIV with DUOPAP, blended high-flow oxygen therapy and advanced synchronisation with Patient Trigger. Optimised for newborns and premature infants up to 10 kg, with the Infant Flow® LP interface for minimal work of breathing.
Model: ZOLL fabian Therapy Evolution
CONCEPT
Personalised non-invasive therapy for the most fragile
Unlike the fabian HFO (focused on HFOV for severe cases) and the fabian +nCPAP Evolution (focused on simple nCPAP + conventional ventilation), the fabian Therapy Evolution is built specifically for the spectrum of high-performance non-invasive therapies: NIV with DUOPAP, blended high-flow oxygen and advanced synchronisation with Patient Trigger. The ideal solution for NICUs that prioritise the "non-invasive first" strategy and want to avoid intubation whenever it is clinically possible.
- NIV with synchronised DUOPAP (Bi-Level Positive Airway Pressure)
- Patient Trigger (optional) — flow-sensitive synchronisation in DUOPAP
- Blended high-flow oxygen therapy (titrated FiO₂)
- PRICO (optional) — automatic FiO₂ control for target SpO₂
- Infant Flow® LP interface — minimal work of breathing
- Automatic leak compensation (essential in neonatal NIV)
SMART FEATURES
Personalisation for each premature infant
The premature lung needs precise pressures, exactly regulated oxygen and perfect synchronisation with its fragile effort. The fabian Therapy Evolution automates critical decisions — the clinician sets the target, the ventilator adjusts breath by breath.
DUOPAP
Bi-Level Positive Airway Pressure
DUOPAP alternates between two CPAP levels (high and low) — it provides additional ventilatory support over simple CPAP, useful for premature infants with inadequate respiratory effort on classic nCPAP. It reduces the need for intubation in moderate distress.
- Two CPAP levels alternated cyclically
- Additional support over simple nCPAP
- Reduces the need for intubation in moderate RDS
- Clinically validated for premature infants and newborns
PATIENT TRIGGER
DUOPAP synchronisation with the patient's effort
A software option exclusive to the fabian Therapy Evolution: Patient Trigger synchronises the transition from the low to the high CPAP level with the newborn's respiratory effort. Combined with a hot-wire flow sensor, it provides continuous respiratory-rate monitoring.
- Low → high CPAP transition synchronised with breathing
- Hot-wire flow sensor — flow-sensitive trigger
- Continuous respiratory-rate monitoring
- Reduces asynchrony and discomfort
PRICO
Automatic FiO₂ control (optional)
PRICO (Predictive Intelligent Control of Oxygenation) keeps the patient within the target SpO₂ range by automatically adjusting FiO₂. Clinical studies show it significantly reduces time in hypoxia and hyperoxia compared with manual control.
- FiO₂ adjusted automatically for target SpO₂
- Reduces time in hypo- and hyperoxia
- Clinically proven more effective than manual control
- Reduces clinical staff workload
OXIGEN FLUX ÎNALT
High-flow blended oxygen therapy
High-flow oxygen therapy with an integrated blender — titrated FiO₂ 21–100%. Indicated as a less invasive alternative to nCPAP in mild respiratory distress, and as a post-extubation transition option.
- Integrated blender — titrated FiO₂ 21–100%
- Compatible with neonatal nasal cannulas
- An alternative to nCPAP in mild distress
- Post-extubation transition
TECHNICAL SPECIFICATIONS
fabian Therapy Evolution operating parameters
| Patients | Neonatal, infant — up to 10 kg |
|---|---|
| Non-invasive therapy modes | nCPAP · DUOPAP · NIV · High-Flow Oxygen Therapy |
| Conventional modes | Available with standard interfaces |
| Patient Trigger | Optional — flow-sensitive synchronisation in DUOPAP |
| PRICO | Optional — automatic FiO₂ control for target SpO₂ |
| Interfața NIV | Infant Flow® LP — nasal prongs and neonatal masks |
| Spațiu mort senzori neonatali | 0,9 mL |
| Flow sensors | Hot-wire anemometer — reusable and single-use |
| Leak compensation | Automatic |
| Internal battery | 2,5 ore |
| FiO₂ | 21 – 100 % (blender integrat) |
| Alarm management | Manual + automatic configurable |
| Compliance | CE marked (Europe). Not FDA-cleared for the USA. |
CLINICAL INDICATIONS
The "non-invasive first" strategy in the NICU
-
Respiratory distress syndrome (RDS)
NIV with DUOPAP — additional ventilatory support over simple nCPAP, reducing the need for intubation in moderate RDS.
-
Mild-to-moderate respiratory failure
Blended high-flow oxygen or DUOPAP — a non-invasive strategy to avoid intubation.
-
Post-extubation support
Transition from invasive ventilation to DUOPAP or high-flow, without re-intubation.
-
NICU dedicat NIV
For NICU wards that prioritise non-invasive strategies — the fabian Therapy Evolution is the ideal model.
-
SpO₂ saturation optimisation
With optional PRICO — FiO₂ adjusted automatically to keep the newborn within the target SpO₂ range.
-
Apnea of prematurity
With Patient Trigger — optimal synchronisation with the newborn's effort during apnea episodes.
FABIAN FAMILY COMPARISON
Which fabian to choose for the NICU?
| Therapy Evolution | +nCPAP Evolution | HFO | |
|---|---|---|---|
| Patients | ≤ 10 kg | ≤ 30 kg | ≤ 30 kg |
| HFOV | — | — | Yes — with active inspiration + expiration |
| FOT | — | — | Yes — exclusive |
| DUOPAP | Yes, primary focus | Limited | Included |
| Patient Trigger | Optional — exclusive | — | — |
| nCPAP + Infant Flow® LP | Yes | Yes — primary focus | Yes |
| Invasive conventional modes | Limited | Yes — extended | Yes — full |
| High-flow O₂ blended | Included | Included | Included |
| PRICO | Optional | Optional | Included |
| Recommended for | "Non-invasive first" NICU, advanced NIV support | General NICU — nCPAP + invasive | Reference NICU — severe RDS, PPHN cases |
DE CE fabian Therapy Evolution
Maximum specialisation in non-invasive therapy
The fabian Therapy Evolution is the only ventilator in the fabian family to offer Patient Trigger for DUOPAP synchronisation — a crucial technology for NICU centres implementing the "non-invasive first" strategy recommended by European neonatology guidelines. Combined with optional PRICO, it becomes the most advanced device for non-invasive therapy of the premature infant.
- The only fabian with Patient Trigger for DUOPAP
- Full suite of non-invasive therapies — nCPAP, DUOPAP, high-flow
- Optional PRICO — FiO₂ control automation
- Built in Switzerland (Acutronic, a ZOLL division)
- CE marked — used in top European NICUs
Interested in the fabian Therapy Evolution?
Hellimed provides technical consulting, clinical demonstrations and training for the fabian Therapy Evolution — for NICUs that prioritise non-invasive strategies. We help you compare it with the fabian HFO and the fabian +nCPAP Evolution.
Request a quote for the fabian Therapy Evolution